Czech Society for Structural Biology
Česká společnost pro strukturní biologii

The Czech Society
for Structural Biology
(Česká společnost
pro strukturní biologii

Videnska 1083
CZ-142 20 Prague
Czech Republic
VAT number: 0022869433
account num.: 2300076583/2010
IBAN: CZ2820100000002300076583

Afiliation: Institute of Biotechnology - BIOCEV, Czech Academy of Sciences, Průmyslová 595, 252 50 Vestec, Prague-West, Czech Republic

Research Interests:

Interaction and recognition of biomolecules, non-bonding interactions
Hydration and solvation of biomolecules (proteins and nucleic acids)
Molecular modeling and simulations (molecular dynamics, enhanced sampling methods)
Computational studies of enzymatic catalysis
Protein engineering and design

Five selected papers

L. Biedermannova, B. Schneider: Structure of the ordered hydration of amino acids in proteins: analysis of crystal structures. Acta Crystallogr. D 2015, 71(11) 2192-2202.
J. Cerny, L. Biedermannova, P. Mikulecky, J. Zahradnik, T. Charnavets, P. Sebo, B. Schneider: Redesigning protein cavities as a strategy for increasing affinity in protein-protein interaction. Interferon-γ receptor 1 as a model. BioMed Research International 2015, ID 716945.
A.V. Malkov, S. Stoncius, M. Bell, F. Castelluzzo, P. Ramirez-Lopez, L. Biedermannova, V. Langer, L. Rulisek, P. Kocovsky: Mechanistic dichotomy in the asymmetric allylation of aldehydes with allyltrichlorosilanes catalyzed by chiral pyridine N-oxides. Chem. Eur. J. 2013 19(28), 9167-9185.
E. Chovancova, A. Pavelka, P. Benes, O. Strnad, J. Brezovsky, B. Kozlikova, A. Gora, V. Sustr, M. Klvana, P. Medek, L. Biedermannova, J. Sochor, J. Damborsky: CAVER 3.0: a tool for the analysis of transport pathways in dynamic protein structures. PLoS Comp. Biol. 2012, 8, e1002708.
L. Biedermannova, Z. Prokop, A. Gora, E. Chovancova, M. Kovacs, J. Damborsky, R.C. Wade: A single mutation in a tunnel to the active site changes the mechanism and kinetics of product release in haloalkane dehalogenase LinB. J. Biol. Chem. 2012, 287(34) 29062-29074.